January 26, 2012

Biosecurity

For the benefit of anyone who hasn’t been following, here’s the story so far: your garden-variety bird flu has always been a bug that combines a really nasty mortality rate (>50%) with fairly pathetic transmission, at least among us bipeds (it doesn’t spread person-to-person; human victims generally get it from contact with infected birds). But ... Ron Fouchier, Yoshihiro Kawaoka, and assorted colleagues set out to poke H5N1 with a stick and see what it might take to turn it into something really nasty.

The answer was: less than anybody suspected. A few tweaks ... turned poor old underachieving bird flu into an airborne superbug that killed 75% of the ferrets it infected. (Apparently ferrets are the go-to human analogues for this sort of thing. I did not know that.) By way of comparison, the Spanish Flu — which took out somewhere between 50-100 million people back in 1918 — had a mortality rate of maybe 3%.

When Fouchier and Kawaoka’s teams went to publish these findings, ... the US National Science Advisory Board for Biosecurity ... strongly suggested that all how-to details be redacted prior to publication. ...[T]hose ... details, the board warned, “could enable replication of the experiments by those who would seek to do harm.”

...The National Science Advisory Board for Biosecurity has a diverse makeup, including representatives from the Departments of Commerce and Energy, Justice, the Interior — and oh, Defense and our old friends at Homeland Security. They’ve already read the details that they would deny to others, and you can be damn sure that none of them are volunteering to have their memories erased in the name of global security... And once the government starts deciding who gets to see what parts of this or that scientific paper, you have in effect (as one online commenter points out) “essentially a biological weapons program”...

Suppression might be a valid option if your enemies have about as much biological expertise as, say, Rick Santorum. That is not a gamble any sane person would make...

On the other hand, you have the very real likelihood of an accidental outbreak; of natural mutation to increased virulence; of the bad guys figuring out the appropriate tweaks independent of Kawaoka’s data. In which case you’ve got a few thousand epidemiologists who’ve been frozen out of the Culture Club, improvising by the seat of their pants as they go up against something that makes the Black Plague look like a case of acne.
Peter Watts at his blog.